As the 执行董事 and Head of Renal Bioscience, 心血管,肾脏和代谢 (CVRM) and a member of the CVRM Review Board, I lead 澳门在线赌城娱乐’s early research strategy on 肾脏疾病 and work closely with our commercial and late-stage development teams.

通过领导澳门第一赌城在线娱乐的早期肾脏研究策略, I help to ensure that we use patient-first thinking and build our scientific understanding of these diseases to identify and validate treatment targets that address unmet clinical needs. I am accountable for delivering new drug targets to the renal portfolio and work with my team to identify and validate novel targets and pathways of interest. My responsibilities include integrating the latest technologies – including 人工智能 (AI)和 数字医疗 解决方案-纳入澳门第一赌城在线娱乐的研究, 并提出潜在的药物靶点供审查, to ensure we are always focused on projects with the greatest potential to improve the lives of patients.

My academic career began with my PhD at the University of Southern Denmark, focusing on vascular resistance in renal blood vessels using 在体外 技术. 在接下来的15年里, I undertook postdoctoral research at the 美国国立卫生研究院 before returning to the University of Southern Denmark where I taught and came to lead a research group. I have acquired extensive experience studying the kidney using 在体外, 在活的有机体内 and translational approaches and since joining 澳门在线赌城娱乐, 我帮助搭建了学术和行业兴趣的桥梁. This has led to collaborations with the Karolinska Institutet and Harvard Medical School, 等. I am also leading an partnership with Benevolent AI to integrate its AI capabilities with 澳门在线赌城娱乐’s scientific excellence to deliver novel targets for chronic kidney disease (CKD).

除了我在澳门在线赌城娱乐的角色, I hold academic positions as 南丹麦大学教授 and 哥德堡 University. My scientific interests are kidney pathophysiology, kidney function and blood pressure regulation. The evidence from our research formed the basis for translational research that is informing novel advances in understanding kidney disease.

My drive to transform our understanding of kidney disease biology includes focusing on areas of widespread, 未满足的患者需求, 如慢性肾病, where diagnosis often comes later and treatments are not available to stop the progression of disease. It continues to be an incredibly rewarding challenge to pioneering the science, explore new scientific areas and lead groundbreaking research.

Pernille B. Laerkegaard汉森 执行董事兼生物科学肾部主管, 心血管,肾脏和代谢 (CVRM), 澳门在线赌城娱乐

代币奖励

最佳合作伙伴联盟,与benevolentai合作(2021年)

丹麦高血压协会

诺华研究奖(2010)

美国国立卫生研究院

杰出研究员奖(2004)

Pernille B. Laerkegaard汉森, 执行董事, 肾部生物科学主任, CVRM.

主要成就

执行董事兼生物科学肾部主管, 心血管,肾脏和代谢 (CVRM), 澳门在线赌城娱乐

2016年至今

执行董事, 肾部生物科学主任, 心血管,肾脏和代谢 (CVRM), 澳门在线赌城娱乐, responsible for the early-stage renal pipeline bringing projects from target identification to clinical trials. I am part of the CVRM review board, leading teams in the discovery phase for 肾脏疾病.

2019 – 2022

Project lead for 澳门在线赌城娱乐/Benevolent AI Chronic Kidney Disease (CKD) collaboration, with the aim to discover new drug targets for CKD employing knowledge graphs and machine learning.

2013年至今

南丹麦大学教授, 将我的研究扩展到学术界, exploring vascular function both in normal physiological settings, 还有心血管和肾脏疾病. 我的主要研究方向是钙通道, adenosine and aldosterone and their involvement in cardiovascular and renal physiology and pathophysiology.

科学出版物


Selecting the right therapeutic target for kidney disease

布瓦尔L,孟席斯RI,威廉姆斯J 等. 前药物杂志. 2022年11月2日;13:97 . 1065. doi: 10.3389 / fphar.2022.971065.

Rare variant contribution to human disease in 281,104 UK Biobank exomes

王,问.R.S.卡斯,K. 等. 自然 597, 527–532 (2021). DOI: 10.1038/s41586-021-03855-y

通过更好的预见性提高生产率

LC. 艾瓦特,RJ. 古德温,SE. Fawell等人. 药物发现世界 18-24, 2018

Editorial overview: 心血管 and renal: Blood pressure regulation and hypertension –hunt for new treatment targets in the kidneys

Pernille BL Hansen, Boye L Jensen. Curr Op Pharmacol, 2015年第21卷,第v-viii页,ISSN 1471-4892DOI: 10.1016/j.coph.2015.02.005.

Functional and pharmacological consequences of the distribution of voltage-gated calcium channels in the renal blood vessels

汉森PB. 物理学报(英文版). 2013年4月,207 (4):690 - 9. DOI: 10.1111 / apha.12070.

Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature

汉森PB, Poulsen CB, Walter S,等. 高血压. 2011年9月,58 (3):464 - 70. DOI: 10.1161 / HYPERTENSIONAHA.111.170845.

Adenosine induces vasoconstriction through Gi-dependent activation of phospholipase C in isolated perfused afferent arterioles of mice

刘建军,刘建军,刘建军,等. 我是Soc Nephrol. 2003年10月,14日(10):2457 - 65. DOI: 10.1097/01.asn.0000086474.80845.25.

Differential expression of T- and L-type voltage-dependent calcium channels in renal resistance vessels

汉森PB, Jensen BL, Andreasen D,等. 中国保监会Res. 2001年9月28日;89(7):630-8. DOI: 10.1161/hh1901.097126.

Veeva ID: Z4-52040
编制日期:2023年2月